Description: Xenotransplantation simulation is a computational model that reproduces the process of organ transplantation between different species. This approach is based on the idea that organs from one animal can be used to replace damaged organs in another, which could help mitigate the shortage of human donors. The simulation uses advanced algorithms and artificial intelligence models to predict how the recipient organism will react to the transplanted organ, considering factors such as genetic compatibility, immune response, and biological interactions. Through these simulations, researchers can explore different scenarios and optimize transplant procedures before conducting experiments in clinical settings. The relevance of this technology lies in its potential to revolutionize regenerative medicine and organ transplantation, offering solutions to critical public health issues. Additionally, xenotransplantation simulation allows for safer and more ethical analysis, reducing the need for testing on animals and humans in the early stages of research. In summary, this tool represents a significant advancement at the intersection of biology, medicine, and artificial intelligence, opening new possibilities for treating terminal illnesses and improving patients’ quality of life.