Description: An unbiased estimator is a fundamental concept in statistics that refers to an estimator whose expected value is equal to the parameter being estimated. In other words, if multiple samples of the same phenomenon were taken and the estimator calculated for each, the average of those estimators would converge to the true value of the parameter. This property is crucial because it ensures that, on average, the estimator does not tend to overestimate or underestimate the true value. Unbiased estimators are valued in scientific research as they provide a solid foundation for inferences and decisions based on data. However, it is important to note that an estimator can be unbiased but not necessarily efficient, meaning it may have high variance. In fields such as bioinformatics, where large volumes of data are analyzed, the choice of unbiased estimators is essential to ensure the validity of results, especially in studies seeking precise relationships from complex and noisy data.