Description: WormBase is a comprehensive database dedicated to the genetics and biology of the nematode Caenorhabditis elegans and related species. This platform provides access to a vast amount of information on genome sequencing, genetic annotations, genetic interactions, and phenotypes. WormBase has become an essential resource for researchers in molecular biology, genetics, and development, facilitating the study of fundamental biological processes. The database includes advanced search tools and interactive visualizations that allow users to efficiently explore data. Additionally, WormBase is regularly updated to incorporate new discoveries and experimental data, ensuring that researchers have access to the most current and relevant information. Its focus on C. elegans, a widely used model organism in biological studies, enables scientists to make comparisons with other organisms and apply findings to human biology and other fields. In summary, WormBase is not just a data repository but also a collaborative platform that supports research and advances knowledge in biology and genetics.
History: WormBase was established in 1998 as a collaborative effort among several research laboratories and has significantly evolved since then. Initially, it focused on the genome sequencing of C. elegans, which was completed in 1998, becoming the first multicellular organism to have its genome fully sequenced. Over the years, WormBase has expanded its scope to include information on other nematode species and has improved its search and visualization tools.
Uses: WormBase is primarily used in genetic and biological research, allowing scientists to access data on genes, proteins, and their functions. Researchers can use WormBase to identify mutations, study genetic interactions, and explore phenotypes associated with different conditions. It is also a valuable tool for education and training in molecular biology.
Examples: An example of using WormBase is in studies on neuronal development in C. elegans, where researchers can access information about specific genes involved in neuron formation and their connections. Another example is the analysis of drug resistance in mutant strains of C. elegans, where WormBase data is used to identify genes that may be related to responses to specific treatments.
