Description: The safety assessment of xenobiotics refers to the systematic process of analyzing and determining the potential impact of chemical compounds foreign to the organism, known as xenobiotics, on human health and the environment. These compounds can include pesticides, pharmaceuticals, industrial pollutants, and food additives, among others. The assessment involves a series of studies that examine the toxicity, exposure, and long-term effects of these compounds. Bioinformatics tools are employed to model molecular interactions, predict toxicity, and analyze large volumes of biological data, allowing for a more accurate and efficient assessment. This approach is crucial for the regulation of chemicals and the protection of public health, as it helps identify risks before xenobiotics are released into the market or the environment. The integration of bioinformatics into the safety assessment of xenobiotics has revolutionized the way these studies are conducted, enabling faster and data-driven analysis, which is essential in a world where exposure to chemical substances is increasingly common.